home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Dialing Down The Heat

  August, 26 2003 7:49
your information resource in human molecular genetics
Uncontrolled inflammation is a chief cause of morbidity and mortality. In the September issue of Nature Immunology, scientists show that a natural molecule in our body known as SIGIRR regulates inflammation by dampening signals that initiate inflammatory responses. This finding helps us to understand how our body keeps inflammation in check and opens new avenues for designing anti-inflammatory treatments.

Our body senses bacteria and viruses with a set of molecules known as Toll-like receptors (TLRs). TLRs belong to a bigger family of molecules that include the interleukin 1 receptor, which is commonly associated with inflammation. Li and colleagues show that SIGIRR, which is a member of this family of molecules, suppresses rather than initiates inflammation. Understanding how SIGIRR is switched on should provide targets for stopping unwanted inflammation.

Author contact:

Xiaoxia Li
Cleveland Clinic Foundation
Cleveland, OH
Tel: +1 216 445 8706
E-mail: lix@ccf.org

Additional contact for comment on paper:

Luke A. O'Neill
Trinity College
Dublin, Ireland
Tel: +353 1 618 2439
E-mail: laoneill@tcd.ie

Also available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.