home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Dendritic Cells key In Orchestrating Respiratory Tolerance

 
  August, 7 2001 2:51
your information resource in human molecular genetics
 
     
Tolerant immunity

The upper respiratory tract is constantly exposed to allergens or substances that can cause an allergic reaction. Under normal circumstances allergens, unlike pathogens, do not provoke an immune response, but instead induce a state of unresponsivesness or tolerance. Sometimes, however, allergens can trigger an immune response, which can lead to the development of asthma

The immunological events surrounding tolerance induction in the lungs are poorly defined. In the August edition of Nature Immunology (Vol. 2, No. 8, pp. 725-731), scientists from Stanford University in California have discovered that dendritic cells, a type of immune cell that detects foreign substances, plays a key role in orchestrating respiratory tolerance. Using an animal model they show that dendritic cells produce interleukin 10 after respiratory exposure to a harmless protein. Interleukin 10 is a type of signaling molecule that stimulates the development of regulatory T cells that suppress or shut down the immune response. Thus, therapies that can induce IL-10 and regulatory T cells may prove useful in treating allergic asthma. Also see the News & Views by Howard Weiner (pp. 671-672).

Dale T. Umetsu
Stanford University Medical Center
Department of Pediatrics, RM G309
Stanford, CA 94305-5208
UNITED STATES
Tel: (+1) 650-498-6073
Fax: (+1)650-498-5560
umetsu@stanford.edu

Howard Weiner
Harvard Medical School
Center for Neurologic Diseases
Brigham and Women's Hospital
77 Ave Louis Pasteur, HIM 720
Boston, MA 02115
UNITED STATES
Tel: (+1) 617-525-5300
Fax: (+1) 617-525-5252
weiner@cnd.bwh.harvard.edu

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.