home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Regulating Susceptibility To Infection By Herpes Simplex Virus

  August, 3 2001 0:48
your information resource in human molecular genetics
Scientists sometimes use pathogens for therapy. The virus responsible for herpes, Herpes Simplex Virus (HSV), can thus be attenuated by genetic engineering, and used to transfer genes to specific cells in gene therapy or in the treatment of cancer.

Specificity is indeed crucial here as, in the case of cancer therapy, ‘suicide’ genes need to be delivered to cancer cells to trigger their self-destruction, and not to healthy cells, which must be spared. Understanding the regulation of a cell’s specificity (permissiveness) to infection by HSV is thus of fundamental importance.

Patrick Lee and his colleagues at the University of Calgary, Alberta, Canada now report in the August issue of Nature Cell Biology (Vol. 3, No. 8) that activation of the Ras signalling pathway increases permissiveness to HSV. They went on to investigate the molecular mechanism of regulation of HSV permissiveness by Ras, and found Ras to regulate activation of the ERK (extracellular matrix-regulated kinase) and PKR (double-stranded RNA-activated protein kinase) kinases. PKR activation is known to result in inhibition of the expression of viral protein expression, thus blocking viral replication.

These findings show that HSV specifically targets cells with an activated Ras signalling pathway. The Ras pathway is constitutively activated in cells expressing oncogenes; it can also be regulated pharmacologically. This study thus paves the way to manipulations of the Ras pathway for the treatment of HSV infection, and also to optimization of engineered HSV in cancer therapy and gene therapy.


Dr Patrick W. K. Lee
tel + 1 403 220 7548
e-mail plee@ucalgary.ca

(C) Nature Cell Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.