PORTRAITS OF HUMAN BREAST TUMOURS
Tumours are as varied as the individuals they afflict, suggests one of two studies investigating breast cancer this week [Nature, Vol. 406, Issue 6797, August 17, 2000]. David Botstein of Stanford University School of Medicine, California, and colleagues used microarray (‘biochip’) technology to analyse the expression of more than 8,000 genes from diverse breast cancer samples. This gives a snapshot of tumour gene activity - a ‘molecular portrait’ - showing how genetic regulation is related to disease and how clinical treatment affects gene regulation.
Most importantly, the work allows a rough ‘taxonomy’ of tumours - classifying them according to genes whose activity is substantially altered. The results could allow more detailed characterization and diagnosis of human breast cancer.
In the second study, Susette C. Mueller of Georgetown University Medical School, Washington DC, and colleagues investigate an enzyme that seems to have a central role in guarding epithelial cells against tumour formation. This enzyme (Syk) is commonly found in normal breast tissue, benign breast lesions and low-tumorigenic breast cancer cell lines, but is low or undetectable in invasive breast carcinoma tissue.
Mueller and colleagues find that introducing Syk genes to a Syk-deficient breast cancer cell line inhibits tumour growth. Conversely, overexpressing crippled Syk enzymes in a breast cancer cell line increases tumour incidence and growth. This makes Syk a potential tumour suppressor in human breast carcinomas, they propose.
tel +1 650 723 3488,
fax +1 650 723 7016,
tel +1 202 687 8484,
fax +1 202 687 7505,
(C) Nature press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking