home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A Natural Ligand For PPAR-Gamma

  July, 10 2008 8:43
your information resource in human molecular genetics

How PPAR-gamma -- a fatty acid receptor that plays a central role in energy metabolism -- is activated by a natural ligand is revealed in a study online in Nature Structural & Molecular Biology. The findings could be useful in the design of better drugs to treat type 2 diabetes.

Dysfunctions in PPAR-gamma are linked to diabetes, cardiovascular disease and obesity, so the receptor is an important target for type 2 diabetes drugs. Previous work had shown that synthetic binding molecules, or ligands, activate PPAR-gamma by making contacts with one specific part of the protein.

Yong Li, Eric Xu and colleagues now show that nitrated linoleic acid, a potent natural ligand, makes contacts with this same region but also with a second one, explaining how it is recognized by PPAR-gamma and why it has such high activity.

Author contacts:

H. Eric Xu (Van Andel Research Institute, Grand Rapids, MI, USA)
E-mail: eric.xu@vai.org

Yong Li (University of Pittsburgh, Pittsburgh, PA, USA)
E-mail: yol21@pitt.edu

Abstract available online.

(C) Nature Structural & Molecular Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.