home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A New Way To Treat Premature Ageing

  July, 10 2008 8:30
your information resource in human molecular genetics

A combination of statins and drugs for bone disorders could treat premature-ageing conditions such as Hutchinson-Gilford progeria syndrome (HGPS), reports a study published online in Nature Medicine.

Several forms of human premature aging, including HGPS, are caused by a mutant protein called progerin. Progerin undergoes a biochemical modification known as prenylation, which anchors it to the membrane of the cell nucleus, leading to the disease. Previous studies showed that inhibitors of the enzyme farnesyltransferase (FT), which is responsible for one form of prenylation, eliminate the nuclear abnormalities associated with progerin accumulation and lead to a small improvement of the aging-like characteristics in a mouse model of progeria.

Now, Carlos López-Otín and colleagues show that progerin is also prenylated by the enzyme geranylgeranyltransferase (GGT), which could explain the low efficiency of the FT inhibitors in previous studies. The authors also show that a combination of cholesterol-lowering drugs -- statins -- and drugs for certain bone disorders -- aminobisphosphonates -- prevents the modification of progerin, markedly improving the aging-like characteristics of progeroid mice, and increasing their life span.

These findings point to a new therapeutic approach for HGPS and other premature-aging syndromes.

Author contact:

Carlos López Otín (Universidad de Oviedo, Spain)
E-mail: clo@uniovi.es

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.