home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Anti-Parasite Protective Mechanism

 
  July, 10 2008 8:26
your information resource in human molecular genetics
 
     

Scientists have discovered how the immune system fights Toxoplasma gondii, a parasite that causes the disease toxoplasmosis in humans, according to a paper online in Nature Immunology.

Immune cells called CD8+ T lymphocytes are required to fight T. gondii, which can cause severe disease in humans with weak immune systems. These cells recognize parasite-derived protein fragments displayed on the surface of infected cells. Nilabh Shastri and colleagues show that a fragment of the T. gondii protein called GRA6 is a target of CD8+ T lymphocytes and induces a protective immune response in mice.

They also showed that the host cell protein ERAAP, which acts as a scissor to 'clip' proteins into fragments, is required for the production of this protective GRA6 fragment. This is the first time ERAAP has been shown to have a specific and protective role in the immune response to pathogens.

Author contact:

Nilabh Shastri (University of California, Berkeley, CA, USA)
E-mail: nshastri@berkeley.edu

Abstract available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.