home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Thirty Loci And Counting For Crohn's disease

  July, 10 2008 8:22
your information resource in human molecular genetics

More than 30 genetic loci have been identified that confer susceptibility to Crohn's disease, a common inflammatory bowel disorder, according to a study published online in Nature Genetics. This is the most complete picture yet assembled of the genetic influences on risk of a common disease.

Three genome-wide scans for Crohn's disease have recently been published, revealing 11 loci that lead to increased risk of the disease. Led by Mark Daly, the authors of those studies have now combined their data and conducted an overall 'meta-analysis', which increases the likelihood of identifying variants with modest effects on disease susceptibility. With this approach an additional 21 loci were found. Together, these 32 loci account for approximately 10% of the overall variance in disease risk, which may reflect as much as 20% of the genetic risk, given a substantial role for environmental factors. The overall picture suggests that there are a small number of loci that confer significant added risk, and a much larger number with smaller effects.

Three of the individual genes that have been implicated in Crohn's disease have previously been shown to influence risk of type 1 diabetes and asthma, raising the possibility of common genetic mechanisms underlying these disorders.

Author contact:

Mark Daly (Harvard Medical School, Boston, MA, USA)
E-mail: mjdaly@chgr.mgh.harvard.edu

Abstract available online.


(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.