home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Study Finds Some People Genetically Predisposed to Tuberculosis

 
  July, 17 2000 18:40
your information resource in human molecular genetics
 
     
In the August issue of The American Journal of Human Genetics, Celia Greenwood and colleagues present evidence for a major genetic component to TB susceptibility. Tuberculosis (TB) is currently a major public health problem worldwide. Although there are millions of new cases of TB each year, not all individuals exposed to TB become infected, nor do all individuals infected with TB develop clinical symptoms. To date, the explanation for variability in TB susceptibility has been unclear. Genetic differences are thought to play a role, but the genes involved have not been identified. Now, Greenwood et al. have discovered a major genetic region that is associated with clinical TB. In their study, people with at least one high-risk copy of this genetic region are ten times more likely to develop TB than normal.

The population on which they performed the study, a group of aboriginal Canadians, was important in providing these definite results. Because TB was rare in Canada until the late 19th century, this group has not been exposed to TB for the many centuries that have people of European descent. In Europeans, it is believed that highly-susceptible individuals have been killed by TB over the past several centuries, leading to natural selection against this genetic susceptibility to TB. In Canada, TB has not been present long enough for natural selection to have proceeded to the same extent, and this was believed to have left the aboriginal populations with individuals at high-risk for TB.

The genetic region identified in these studies contains a gene, NRAMP1, that is known to be involved in susceptibility to leprosy, which is caused by a bacterium related to TB. It is therefore likely that genetic variation in NRAMP1 gives rise to the range of TB susceptibility in this population. Additional studies are required to understand the role of NRAMP, if any, in the development of TB, but an increased understanding of the specific gene(s) involved in TB susceptibility should lead to better control of infection and better treatment for this disease.

For the full text of this article, entitled "Linkage of Tuberculosis to Chromosome 2q35 near NRAMP1 in a Large Aboriginal Canadian Family",see the "August 2000"section in the electronic edition of The American Journal of Human Genetics at http://www.ajhg.org.

For more information, contact Dr. Celia Greenwood at the Division of Medical Genetics, Montreal General Hospital. Phone: (514)937-6011 x 4627. Email: celia@bagel.epi.mcgill.ca

Contributed by Dr. Kate Beauregard, The American Journal of Human Genetics, Tel: (404)712-9985. Email: kbeaure@emory.edu


Message posted by: Kate Beauregard

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.