home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Improving Stroke Therapy

  June, 26 2008 9:02
your information resource in human molecular genetics
The mechanism that may cause the undesirable bleeding associated with blood clot 'dissolving' enzymes is described in a paper published online in Nature Medicine.

Cases of stroke caused by blood clots can be treated with tissue plasminogen activator (tPA), which 'dissolves' the clot but they can also lead to the nasty side effect of cerebral bleeding.

Daniel Lawrence and colleagues report that an intracerebral injection of tPA increases the permeability of cerebral blood vessels by activating a molecule known as platelet-derived growth factor-CC (PDGF-CC). Injection of PDGF-CC has an effect on blood vessels similar to that of tPA, whereas co-injection of antibodies against PDGF-CC blocks the increased permeability caused by tPA.

The authors also found that the effects of PDGF-CC depend on the activation of PDGF-alpha receptors present on brain cells lining the blood vessels. The treatment of mice with the PDGF-alpha receptor antagonist imatinib (Gleevec), which is clinically used to treat certain blood cancers, reduces vascular permeability and the hemorrhagic complications of tPA administration after stroke.

These results reveal a role for PDGF signaling in the regulation of the blood-brain barrier and identify imatinib as a potential drug to reduce the complications associated with the use of tPA in stroke.

Author contact:

Daniel Lawrence (University of Michigan Medical School, Ann Arbor, MI, USA)
E-mail: dlawrenc@umich.edu

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.