home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A Drug Against Blood Cancer May Also Fight Lupus

  June, 12 2008 8:50
your information resource in human molecular genetics

A drug used to treat multiple myeloma, a cancer of the white blood cells, could also be useful for the treatment of the chronic autoimmune disease lupus erythematosus. A study published online in Nature Medicine suggests that this may lead to new treatment strategies for other antibody-mediated diseases.

Diseases like myasthenia gravis and systemic lupus are caused by autoantibodies produced by long-lived immune cells that show very high rates of protein generation. As myeloma cells respond to treatment with proteasome inhibitors, and their sensitivity correlates with their rates of protein synthesis, Reinhard Voll and his colleagues suggest that, in mice with lupus-like disease, those inhibitors would have a similar effect on the autoantibody-producing cells.

Using two mouse strains with 'lupus' they show that the proteasome inhibitor bortezomib -- a drug approved for the treatment of multiple myeloma -- blocks autoantibody production and prolongs survival of the mice. So, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-associated diseases.

Author contact:

Reinhard Voll (University of Erlangen-Nuremberg, Erlangen, Germany)
E-mail: rvoll@molmed.uni-erlangen.de

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.