home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Prognostic Marker For Breast Cancer

 
  June, 12 2008 8:40
your information resource in human molecular genetics
 
     
Scientists have identified a genetic variant that strongly predicts poor survival among women with breast cancer, particularly after treatment with a commonly used form of chemotherapy, according to a study published online in Nature Genetics.

The enzyme NQO1 protects cells from the damaging effects of oxidative stress. A common variant of NQO1 called NQO1*2, present in 4-20% of the human population, effectively eliminates production of the enzyme. Heli Nevanlinna, Jiri Bartek and colleagues carried out the first study investigating the NQO1*2 as a predictive factor for treatment in breast cancer by genotyping over 2,000 women with breast cancer in Finland and following the outcome of their disease and treatment.

Women with two copies of NQO1*2 who were treated with the drug epirubicin had a survival rate of only 17%, compared to 75% for women who had no copies or one copy of the NQO1*2 variant. The presence of NQO1*2 also had a significant effect on survival after metastasis. Given the large number of individuals who carry NQO1*2 -- up to 20% in Asian populations -- the authors suggest that NQO1 genotype could be an important predictive factor for treatment. They call for a randomized prospective clinical trial comparing epirubicin treatment with alternatives to validate the predictive potential of NQO1*2.

Author contacts:

Heli Nevanlinna (Helsinki University Central Hospital, Finland)
E-mail: heli.nevanlinna@hus.fi

Jiri Bartek (Danish Cancer Society, Copenhagen, Denmark)
E-mail: jb@cancer.dk

Carl Blomqvist (Helsinki University Central Hospital, Finland)
E-mail: carl.blomqvist@hus.fi

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.