home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Following Mitochondria In Mouse Neurons

 
  June, 14 2007 20:02
your information resource in human molecular genetics
 
     
A set of tools to study transport of mitochondria in neurons is presented in the July 2007 issue of Nature Methods.

The proper function and distribution of mitochondria, the much-described 'powerhouses of the cell', are important in neuronal physiology. Disruptions of these organelles are suspected to play a role in the pathology associated with neurodegenerative conditions like amyotrophic lateral sclerosis, as well as Parkinson's and Alzheimer's diseases. But studies on the neuronal transport of mammalian mitochondria have largely been done in the tissue culture dish.

Jeff Lichtman and colleagues now present mice in which the neuronal mitochondria as well as the neurons themselves have been labelled with genetically-encoded fluorescent proteins. In contrast to a previously published report of similar transgenic mice, here the authors demonstrate the utility of these models to study axonal transport in vivo. The movement of mitochondria can be imaged either in live mice or in acute nerve-muscle explants, which more closely resemble the in vivo setting than isolated neuronal cells. The researchers were also able to damage selected nerves in vivo and study changes in transport of the mitochondria through the nerves in the damaged region.

Author contact:

Jeff Lichtman (Harvard University, Cambridge, MA, USA)
E-mail: jeff@mcb.harvard.edu

Abstract available online.

Nature Methods.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.