home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Genetic Variants Predisposing To Celiac Disease

  June, 14 2007 19:59
your information resource in human molecular genetics
A region containing four closely linked genes on chromosome 4 harbours variants that protect against the development of celiac disease, according to a study to be published online in Nature Genetics. Celiac disease is an autoimmune disorder of the small intestine that is caused by a reaction to a gluten protein found in wheat, rye and barley, requiring affected individuals to eat a gluten-free diet.

David van Heel and colleagues carried out a genome-wide association study for celiac disease, initially looking at a group of affected and unaffected individuals in the UK. In addition to associations in the HLA region, which had been reported previously, they identified a protective variant in a region that contains the genes IL2, IL21, TENR, and a predicted gene of unknown function, KIAA1109. This association was replicated in populations from the Netherlands and from Ireland. The genes IL2 and IL21 are considered the two most promising genes to explain the association, as they encode interleukin-2 and interleukin-21, proteins known to be involved in other intestinal inflammatory diseases. Further mapping of this region will be required to pin down the mechanisms by which these variants protect against celiac disease.

Author contact:

David van Heel (Queen Mary University of London, UK)
E-mail: d.vanheel@qmul.ac.uk

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.