home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

MicroRNAs And Tumour Suppression

 
  June, 14 2007 19:54
your information resource in human molecular genetics
 
     
The tumour suppressor p53 acts directly on a family of small RNAs that are vital for cell growth and replication, according to a paper published online in Nature. Already well known for its indirect effects, p53 is now shown to target the miR-34 family of microRNAs (miRNAs), which itself suppresses cell proliferation.

A global decrease in miRNA levels is often observed in human cancers, indicating that small RNAs may have a part to play in tumour suppression. However, little is known about how miRNA expression is regulated. Gregory J. Hannon and colleagues compared the miRNA expression profiles of wild-type and p53-deficient mouse cells. They identified a family of non-coding miRNAs - miR-34 - that is the direct target of, and thus regulated by, p53, and show that the ectopic expression of these miRNAs leads to growth arrest and, in some cases, cell senescence. This suggests that the miR-34 family acts as components of p53-mediated growth and arrest pathways, and the authors describe several miR-34 target genes that have roles in cell cycle progression.

miR-34 is one of only 18 mammalian miRNA families that are also present in Drosophila and the nematode worm Caenorhabditis elegans. This raises the possibility that the link between p53 and miR-34 might have arisen early in the evolution of the p53 network and may be important in p53 function in diverse species, the authors speculate. The paper represents one of the first discoveries of direct transcriptional regulators for miRNAs and is likely to be the tip of the iceberg.

CONTACT

Gregory J. Hannon (Cold Spring Harbor Laboratory, NY, USA)
E-mail: hannon@cshl.org

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.