home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Mechanism Of Motor Neuron Disease

  June, 28 2005 8:53
your information resource in human molecular genetics
A study in the July issue of Nature Genetics reports a new mechanism underlying motor neuron disease, which may be broadly relevant to several adult-onset neurodegenerative diseases, including amyotrophic lateral sclerosis, Huntington disease, Parkinson disease and Alzheimer disease.

Mutations in the gene encoding dynein, a molecule involved in transporting cargo in neuronal cells, had previously been shown to cause motor neuron disease. David Rubinsztein and colleagues now show that reduced dynein function impairs the clearance of protein aggregates from affected neurons. These aggregates (also called inclusions) are a common feature of several neurodegenerative diseases, and are possibly toxic to the cells. The authors suggest that dynein may normally be responsible for transporting the aggregate-clearing protein complex to its proper location in the neuron.

Author Contact:

David Rubinsztein (Cambridge Institute for Medical Research, UK)
Email: dcr1000@hermes.cam.ac.uk

Also available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.