home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Cancer Chemoprevention By The Antioxidant Tempol Acts Partially Via The P53 Tumor Suppressor

 
  June, 14 2005 12:33
your information resource in human molecular genetics
 
     
Cancer Chemoprevention By The Antioxidant Tempol Acts Partially Via The P53 Tumor Suppressor

Published in: Human Molecular Genetics 2005 14(12):1699-1708.

Authors: Laura Erker, Ralf Schubert, Hiroyuki Yakushiji, Carrolee Barlow, Denise Larson, James B. Mitchell5 and Anthony Wynshaw-Boris.

Affiliations:
Department of Pediatrics, Department of Medicine and Comprehensive Cancer Center, UCSD School of Medicine, La Jolla 92093, USA.

Genetic Disease Research Branch, NHGRI, NIH, Bethesda, MD 20892, USA.

Radiation Biology Branch, NCI, Bethesda, MD 20892, USA

This paper reports that the tempol treatment of cancer-prone p53-deficient mice resulted in a small but significant (25%) increase in lifespan by prolonging latency to tumorigenesis, demonstrating that existing oxidative stress and damage are not necessary for the chemopreventative effects of tempol. However, according to the authors, the relatively small effect on latency in p53-deficient mice and the finding that tempol-mediated resistance to oxidative insult was p53-dependent suggested a more direct role of p53 in the chemopreventative effects of tempol.

The authors conclude that the chemopreventative effect of tempol is not solely due to the reduction of oxidative stress and damage but may also be related to redox-mediated signaling functions that include p53 pathway activation.

Correspondence should be addressed to:

Anthony Wynshaw-Boris
San Diego School of Medicine, University of California, 9500 Gilman Drive, Mailstop 0627, La Jolla, CA 92093-0627, USA.
Email: awynshawboris@ucsd.edu

{Ralf Schubert} Present address: Department of Pediatrics, J. W. Goethe-University, Frankfurt, Germany.

{Hiroyuki Yakushiji} Present address: Department of Surgery, Taku Hospital, Saga, Japan.

{Carrolee Barlow} Present address: BrainCells Inc., San Diego, CA, USA.

Also published online

(C) Human Molecular Genetics.

Posted by: Tressie Dalaya.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.