home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Oral Insulin Does Not Prevent Type 1 Diabetes

 
  June, 24 2003 13:55
your information resource in human molecular genetics
 
     
Insulin taken orally does not delay or prevent type 1 diabetes in people at moderate risk (25 to 50 percent likelihood) of developing type 1 diabetes in 5 years, researchers reported today at the annual meeting of the American Diabetes Association. The finding emerged from the second trial conducted as part of the Diabetes Prevention Trial-Type 1 (DPT-1), which ended last month. The other DPT-1 trial, completed two years ago, found that low-dose insulin injections failed to prevent or delay type 1 diabetes in people at high risk (50 percent or greater chance) of developing the disease in 5 years.

A total of 372 people took part in the trial comparing the rate of progression to type 1 diabetes among those randomized to take a daily capsule of insulin crystals (7.5 mg.) or a placebo consisting of a harmless, inactive substance. All participants had a 25 to 50 percent chance of developing type 1 diabetes in the next 5 years, a calculation based on genetic, immunologic, and metabolic tests done before enrollment. Upon joining the trial, which began in 1996, all subjects were making normal amounts of their own insulin. Their ages ranged from 3 to 45 years old, with a median age of 10 years.

After an average of 4.3 years of observation, about 35 percent of people developed type 1 diabetes in each group. The annual rate of onset (7.2 percent per year) was nearly the same in both groups. Testing done as part of the study detected most cases of diabetes before symptoms developed, enabling patients to get prompt, early treatment. No side effects were linked to oral insulin.


For more information, go to:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

CONTACT:
Joan Chamberlain
(301) 496-3583


Message posted by: Rashmi Nemade

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.