home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Deconstructing Dengue Fever

  June, 17 2003 4:51
your information resource in human molecular genetics
Dengue hemorrhagic fever is a peculiar illness: rather than develop resistance, people with the fever often get sicker the second time they are infected. In a study of Thai volunteers, published in the July issue of Nature Medicine, Gavin Screaton and colleagues have discovered why.

Infection with any of the four subtypes of the dengue virus mobilizes immune cells that promote virus destruction. But in volunteers infected a second time with a different strain, immune cells seemed to be of low affinity for the infecting virus and instead mobilized mainly against previously encountered strains. This misdirected immune response barely fights off the new infection. What’s more, some immune cells seem to self-destruct, exacerbating the problem.

The phenomenon, dubbed ‘original antigenic sin’, presents a barrier to vaccine development. Any vaccine could in principle act like an original infection, and could promote dengue infection instead of protecting against it. The new results should help break down barriers to vaccine development for this mosquito-borne disease.

Worldwide, hundreds of thousands of people contract dengue hemorrhagic fever each year, and many require hospitalization. Most of the deaths from this virus occur after a second infection.

Author contact:

Gavin Screaton
John Radcliffe Hospital
Oxford, UK
Tel: + 44 1865 222442/222403
E-mail: screaton@molbiol.ox.ac.uk

Also available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.