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Receptors Mediate Antidiabetic Effects

  June, 17 2003 4:28
your information resource in human molecular genetics

Fat cells manufacture and secrete adiponectin - a hormone that circulates through our blood and has antidiabetic and anti-atherogenic properties. A Letter in this week's Nature (Vol. 423, No. 6941, dated 12 June 2003, pp. 762-769) features the identification of receptors that seem to mediate adiponectin’s beneficial effects.

It is believed that adiponectin helps to regulate our blood sugar levels by stimulating insulin-mediated uptake of glucose in skeletal muscle, and by reducing the insulin-mediated glucose production in the liver. Takashi Kadowaki and colleagues cloned two receptors for adiponectin: one abundantly present in skeletal muscle and another predominantly expressed in the liver.

It is expected that the identification of adiponectin receptors 1 and 2 will boost our understanding of how adiponectin works - as its precise mechanism of action is not yet known. Furthermore, the receptors are potential drug targets, and their identification will aid the design of drugs for obesity-linked diseases, such as diabetes and atherosclerosis.


Takashi Kadowaki
University of Tokyo and CREST
JST, Japan
Tel: +81 3 5800 8818
E-mail kadowaki-3im@h.u-tokyo.ac.jp

(C) Nature press release.

Message posted by: Trevor M. D'Souza

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