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Nicotine is the primary compound in tobacco that establishes andmaintains tobacco dependence. Rachel F.Tyndale and colleagues fromthe University of Toronto,Canada , show that individuals who lackfully functional CYP2A6 , and who therefore have impaired nicotinemetabolism , are significantly protected against becomingtobacco-dependent smokers.In addition , smokers whose nicotine metabolismis thus impaired smoke significantly fewer cigarettes than thosewith normal nicotine metabolism.Nature 24 June 1998 (pp750)Contact: Rachel F.Tyndale tel +1 416 978 6374, fax +1 416 978 6395,e.mail r.tyndale@utoronto.ca
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Message posted by: Firouzeh Biramijamal
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