home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Genetic Differences in Blood Pressure Enough to Affect Heart Risks

 
  May, 21 2009 9:13
your information resource in human molecular genetics
 
     

Small genetic differences between individuals contribute small differences in blood pressure that are sufficient to present different risks of heart attack and stroke, according to two large genome-wide scans published in Nature Genetics .

The Global BPgen and the CHARGE consortium examined genetic markers across the genomes of 63,569 individuals of European descent and found 11 regions that were associated with commonly-measured pumping heart and relaxing heart blood pressures or clinically-diagnosed high blood pressure.

The proportion of blood pressure variation explained by ten genetic variants in the new studies is small -- about 1% after taking into account age, gender and body mass index. However, when acting together in combination, the variants were calculated to be sufficient to account for an increased blood pressure that is associated in epidemiological studies with a 34% increase in risk for stroke and a 21% increase in risk of coronary artery events such as heart attacks. High blood pressure can be lowered to a healthy range by losing weight, reducing salt intake, exercising, reducing alcohol consumption, or by antihypertensive medication.

Author Contacts

Daniel Levy (National Heart, Lung, and Blood Institute, Framingham, MA, USA)
E-mail: levyd@nhlbi.nih.gov

Christopher Newton-Cheh (Massachusetts General Hospital, Boston, MA, USA)
E-mail: cnewtoncheh@chgr.mgh.harvard.edu

Abstracts available online:
Abstract of Paper 1.
Abstract of Paper 2.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.