home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Easing the Way to Pluripotency

  May, 7 2009 9:11
your information resource in human molecular genetics

Tools to selectively drive the expression of genes in pluripotent stem cells while leaving differentiated cells untouched are reported online in Nature Methods.

Induced pluripotent stem (iPS) are made by reprogramming mature cells; they have the potential to differentiate into different mature cell types, but the process of reprogramming is very inefficient.

James Ellis and colleagues describe how virus-derived vectors that drive gene expression exclusively in iPS cells improve the selection of iPS cells. The authors use these vectors to impart antibiotic resistance to emerging iPS cells by driving the expression of an antibiotic resistance gene. Ellis and colleagues derive mouse and human iPS cells modeled for the neurodevelopmental disorder Rett syndrome. This new method will prove useful for studying diseases in the laboratory since it simplifies the isolation of both mouse and human iPS cell lines.

The approach is likely to be particularly useful for making test tube models of diseases, where iPS cells are derived by reprogramming cells of patients with a particular disorder.

Author contact:

James Ellis, SickKids Hospital, Toronto, Canada
E-mail: jellis@sickkids.ca

Abstract available online.

(C) Nature Methods press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.