A mouse model that for the first time mimics the levels of genomic instability in human cancers is presented in Nature. The authors show that mouse and human tumours show similar genetic alterations, and suggest that future research should use this mouse model to understand the genetics of human cancer better.
Ronald DePinho, Lynda Chinand, and colleagues engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery. Using a comparative genomics approach they identified mutated genes in the model that are also altered in human T-cell acute lymphoblastic lymphomas and/or in a diverse range of other tumours. The researchers demonstrate a complexity and comparability in the human and mouse oncogenes that they believe means mouse models of tumours with a high degree of genomic instability will be a valuable resource for investigating complex human cancer genomes.
Ronald A DePinho (Dana Farber Cancer Institute, Boston, MA, USA)
Abstract available online>.
(C) Nature press release.
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