home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Genome-Wide Association Study Of Bipolar Disorder

  May, 17 2007 9:59
your information resource in human molecular genetics
A study suggesting that bipolar disorder may be a polygenic disorder is to be published online in the journal Molecular Psychiatry. This first genome-wide association study of bipolar disorder has implications for the way future studies should approach research into the genetics of the condition.

Bipolar disorder, also known as manic-depression, is a psychiatric condition defined by periods of extreme mood. One in every 100 individuals is diagnosed as having bipolar disorder and they have a high risk of becoming suicidal. Francis J. McMahon and colleagues carried out a study using pooled DNA from two independent case-control samples of European ancestry. The case sample consisted of unrelated individuals selected from families with at least one affected sibling pair, while the control sample consisted of individuals who did not meet criteria for major depression and denied a history of bipolar disorder or psychosis. Over 550,000 single-nucleotide polymorphisms (SNPs) were used to measure the genetic variation between the samples. SNPs that occurred more often in the people with bipolar disorder were examined individually. No one gene appears to be necessary or sufficient for disease. Instead, several genes, each of modest effect, were shown to contribute to the risk of bipolar disorder - with each person's disease risk being influenced by the total burden of risk alleles they carry. Several of the implicated genes lie within regions previously linked to Schizophrenia.

One of the identified genes, DGKH, did stand out for having the strongest result in the study. DGKH encodes diacylglycerol kinase eta, a key protein in the lithium-sensitive phosphatidyl inositol pathway. The phosphatidyl inositol pathway has been hypothesized to play a role in the mechanism of action of mood-stabilizing medications.

Author contact:

Francis J. McMahon (National Institute of Mental Health, NIH, Bethesda, MD, USA)
E-mail: mcmahonf@mail.nih.gov

Editorial contact:

Ogechi Okoli (Nature Publishing Group, London)
E-mail: o.okoli@nature.com

Abstract available online.

(C) Molecular Psychiatry press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.