The identification of a second protein target for modification by the Fanconi anaemia (FA) complex, which is important in DNA repair, is reported online in Nature Structural & Molecular Biology. Mutations in FA-related genes are associated with developmental defects, bone marrow failure, and predisposition to cancer.
Tony Huang and colleagues initially identified the new protein target, called FANCI, by its similarity to the only other known substrate of the FA complex, FANCD2. Their data suggest interdependent roles for FANCI and FANCD2 in promoting DNA repair. The authors also identify mutations in FANCI in four Fanconi anaemia individuals who did not have defects in any of the known FA genes, adding further support that FANCI is an important component in the FA DNA repair pathway.
Tony T. Huang (NYU School of Medicine, New York, NY, USA)
Abstract available online.
(C) Nature Structural & Molecular Biology press release.
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