home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Genetic Risk Factor For Type 2 Diabetes

  May, 2 2007 21:40
your information resource in human molecular genetics
Variation in the gene called CDKAL1 is associated with risk of developing type 2 diabetes, according to a study to be published online in Nature Genetics.

Valgerdur Steinthorsdottir and colleagues discovered this new risk variant through a large-scale survey in Iceland in which they compared the frequencies of several hundred thousand common genetic variants in healthy individuals with those who have the disease. They subsequently replicated the association between type 2 diabetes and a variant in CDKAL1 in samples from several independent populations of European or Han Chinese ancestry. Individuals with two copies of the risk variant were found to be at increased risk for developing disease compared to individuals with only a single copy of the risk variant. Such individuals also had approximately 20% less insulin response than individuals with only one copy or non-carriers, suggesting that the variant may confer risk of type 2 diabetes through reduced insulin secretion.

Author contacts:

Edward Farmer (Director of Corporate Communication, deCODE genetics Inc)
E-mail: edward.farmer@decode.is

Valgerdur Steinthorsdottir (deCODE Genetics, Reykjavik, Iceland)
E-mail: vstein@decode.is

Kari Stefansson (deCODE Genetics, Reykjavik, Iceland)
E-mail: kstefans@decode.is

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.