home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Chromatin Link To Mental Retardation

  May, 2 2007 21:37
your information resource in human molecular genetics
A protein previously implicated in mental retardation has now been shown to influence gene expression by modifying histones. The finding, appearing in a paper published online by Nature, may shed light on a molecular mechanism behind neurological disorders.

Histones are the major proteins that package DNA into chromatin to form chromosomes. Enzymes can add or remove modifications such as methyl groups to these histones and in turn influence DNA-based events such as gene transcription. Yujiang Shi and colleagues have shown that a protein called SMCX (or JARID1C) acts as a demethylating enzyme. The molecule removes tri-methyl groups from histone H3 at lysine residue 4 and can repress transcription of certain neuronal genes.

The gene encoding SMCX is frequently mutated in X-linked mental retardation, in which defects in genes on the X chromosome are inherited. Mutations in SMCX might contribute to disease by impairing regulation of neuronal genes.

Author contact:

Yujiang Shi (Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA)
E-mail: yujiang_shi@hms.harvard.edu

Jessica Podlaski (Media Relations Coordinator, Brigham and Women's Hospital, Boston, MA, USA)
Email: jpodlaski@partners.org

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.