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Paper Title: Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Authors: Roberto Chiarle et al. Journal: Nature Medicine, June 2005. The authors show by gene targeting that Stat3 is required for the transformation of mouse embryonic fibroblasts in vitro, for the development of B-cell lymphoma in transgenic mice and for the growth and survival of both human and mouse NPM-ALK–transformed B and T cells. Pharmacological ablation of Stat3 represents a new candidate approach for the treatment of human lymphoma. Author Contact: Giorgio Inghirami
Department of Pathology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
E-mail: inghig01@med.nyu.edu Also available online. (C) Nature Medicine.
Message posted by: Trevor M. D'Souza
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