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Stat3 Is Required For ALK-Mediated Lymphomagenesis

 
  May, 31 2005 10:53
your information resource in human molecular genetics
 
     
Paper Title: Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

Authors: Roberto Chiarle et al.

Journal: Nature Medicine, June 2005.

The authors show by gene targeting that Stat3 is required for the transformation of mouse embryonic fibroblasts in vitro, for the development of B-cell lymphoma in transgenic mice and for the growth and survival of both human and mouse NPM-ALK–transformed B and T cells.

Pharmacological ablation of Stat3 represents a new candidate approach for the treatment of human lymphoma.

Author Contact:

Giorgio Inghirami
Department of Pathology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
E-mail: inghig01@med.nyu.edu

Also available online.

(C) Nature Medicine.


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