Paper Title: Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Authors: Roberto Chiarle et al.
Journal: Nature Medicine, June 2005.
The authors show by gene targeting that Stat3 is required for the transformation of mouse embryonic fibroblasts in vitro, for the development of B-cell lymphoma in transgenic mice and for the growth and survival of both human and mouse NPM-ALK–transformed B and T cells.
Pharmacological ablation of Stat3 represents a new candidate approach for the treatment of human lymphoma.
Department of Pathology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
Also available online.
(C) Nature Medicine.
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