home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Enhancing incorporation of stem cells

 
  May, 11 2004 10:40
your information resource in human molecular genetics
 
     
Adult stem cells offer great therapeutic potential for a variety of diseases through their capacity to replenish diseased cells and tissue. At present, however, it remains a real challenge to induce efficient repopulation of target tissues by stem cells. Now, research in the May issue of Nature Cell Biology shows that bone marrow stem cells from mice, missing a gene known to inhibit cell division, can overcome this hurdle to a great extent.

Tao Cheng and colleagues used mutant mice lacking a protein, p18, which normally inhibits cell division in mammalian cells and is implicated in several cancers. They find that, compared with normal stem cells, the stem cells isolated from this mutant are much more efficient at repopulating an injured bone-marrow tissue. This was apparently due to increased division of the mutant stem cells, resulting in a larger cell population and thus a competitive advantage.

It seems that the p18INK4C protein normally inhibits the division and self-renewal of bone-marrow stem cells, and so blocking its function may be a productive way to enhance the efficacy of stem cell transplantation in disease models.

Author contact:
Tao Cheng (University of Pittsburgh Cancer Institute, PA, USA)
Tel: +1 412 623 3249, E-mail: chengtao@pitt.edu

Also available online.

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.