home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Telomeres: End In Sight

 
  May, 28 2002 0:01
your information resource in human molecular genetics
 
     
Telomeres are the ends of our chromosomes. Made of many repeats of the same DNA sequence, they act like shoelace caps: they protect the gene-containing body of the chromosome from being worn down. Breakdowns in telomere maintenance are implicated in ageing and cancer.

Telomeric DNA sequences can form four-stranded structures. Online this week in Nature, Stephen Neidle and colleagues of the Institute of Cancer Research, London, describe the crystal structure of one such quadruplex grown at a potassium concentration like that inside a human cell. The folding and appearance of the DNA in this quadruplex is fundamentally different from previously published sodium-containing structures.

The new DNA structure suggests a straightforward path for telomere folding and unfolding. The quadruplexes are flat and propeller-shaped, and can form long stacks one on top of the other with their "blades" sticking out on all sides. This makes them easily recognizable by telomere-associated proteins.

Author contact:

Stephen Neidle
The Institute of Cancer Research,
London, UK

Tel: +44 7970 6043
E-mail: s.neidle@icr.ac.uk

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.