home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Stressed Out Cells

  May, 28 2001 23:50
your information resource in human molecular genetics
Nature Immunology pages 515-522
News and Views pages 478-480

White blood cells continuously patrol the body, via the blood and lymphatic system, to defend it against invading microorganisms. Once an infection is detected, the white blood cells must migrate from the blood to the site of tissue injury. This involves the cells crossing the wall of the blood vessels in a four-step process called transmigration. Using adhesion molecules, the cells initially attach to the cell wall where they ‘roll’ or survey the cell surface. When rolling cells come into contact with signaling molecules called chemokines, the cells stop rolling and adhere more firmly to the wall of the blood vessel. In the final step the white blood cells squeeze through gaps in the wall of the blood vessels.

In the June issue of Nature Immunology (Vol. 2, No. 6), scientists from Israel have discovered another step in white blood cell transmigration. They show that chemokines are not only required to stop the cells rolling but are also needed for white blood cells to squeeze though the wall of the blood vessel. In addition, continuous force or shear stress from fast flowing fluid must be applied on adherant white blood cells to facilitate migration. Thus, both signaling molecules and mechanical forces operate to allow efficient migration of white blood cells throughout the body.

Francis Luscinskas, of Brigham and Women’s Hospital, discusses this paper in an accompanying News & Views.

Ronen Alon
Weizmann Institute of Science
Department of Immunology
Rehovot, 76100
Tel: (+972) 8-9342482
Fax: (+972) 8-9344141

Francis W. Luscinskas
Brigham and Women's Hospital
Department of Pathology
LMRC Bldg, Rm 401a
221 Longwood Avenue
Boston, MA 02115
Tel: (+1) 617-732-6004
Fax: (+1) 617-732-5933

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.