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'heating up' gene expression

  May, 22 2001 0:26
your information resource in human molecular genetics
'Silent' DNA speaks up for the first time

By moderately raising the temperature of cells, biologists have broken through what was considered an impermeable barrier that kept half the genes in some cells "silent." The surprising results, in which these heated genes reached 500 times their normal rate of expression, could lead to better understanding of cellular processes involved in aging, fever and toxicity.

Tom Garritano
National Science Foundation

Edward A. Sekinger and David S. Gross
Silenced Chromatin Is Permissive to Activator Binding and PIC Recruitment
Cell 2001 105: 403-414. [Summary] [Full Text]

Message posted by: Wouter Kalle

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