home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Yeast Vaccine Could Be Used To Immunize Against Cancers And Infectious Diseases

  May, 6 2001 20:44
your information resource in human molecular genetics
Yeast: The Basis For Powerful New Vaccines

Vaccines that cause the production of antibodies alone to menacing antigens are not powerful enough to combat diseases such as HIV and cancer. Thus, scientists are currently trying to develop vaccines that stimulate the second half of the immune response called the cell-mediated response. The latter involves the stimulation of cells called cytotoxic T lymphocytes that produce chemicals that kill the offending pathogen. Richard Duke and colleagues at Ceres Pharmaceuticals have developed the prototype for such a vaccine using the simple yeast Nature Medicine (Vol. 7, No. 5, 01 May 01).

The scientists engineered yeast cells to express an HIV antigen. They vaccinated mice with the yeast vaccine and discovered that the cytotoxic T lymphocytes that the mice produced were powerful and specific enough to destroy only those cells containing a fraction of the HIV virus.

The novel yeast vaccine works by activating a group of immune cells called dendritic cells (DC). These cells absorb the yeast and any antigens it is carrying, process the antigens and then present them on the cell surface. This triggers a strong immune reaction which also includes the release of a potent chemical called interleukin-12.

The authors propose that such a yeast vaccine could be used to immunize against several different types of cancers and infectious diseases.


Dr Richard C. Duke
University of Colorado Cancer Center
Ceres Pharmaceuticals
1899 Gaylord Street
Denver, Colorado 80262
Email: cerespharm@aol.com

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.