home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Human Genes Corrected

 
  April, 5 2005 10:02
your information resource in human molecular genetics
 
     
With a discovery published online in Nature that could herald an alternative to gene therapy, Michael Holmes and his colleagues demonstrate a new way to correct disease-causing mutations in human DNA.

Researchers have struggled to perfect gene therapy, in which they try to compensate for defective genes by inserting a new working copy into cells. Gene correction takes a different approach: repairing the mistakes in DNA that cripple the gene.

Holmes' team fused a zinc-finger protein, which recognizes three to four base pairs in DNA, to a nuclease, which cuts DNA at that sequence. These 'zinc-finger nucleases' are known to trigger homologous recombination, a process by which the surrounding segment of DNA is replaced by a fresh copy.

The team designed a zinc-finger nuclease that recognizes the mutation underlying X-linked severe combined immune deficiency (SCID) - children with this condition can suffer life-threatening infections soon after birth. Holmes and co-workers showed that the nuclease prompted correction of the defect in a high frequency of T cells - the cells affected by the disorder. The study offers the prospect that zinc-finger nucleases could be engineered against any disease-causing mutation in the human genome, and used to treat the disease.

Author contact:

Michael Holmes (Sangamo, BioSciences, Richmond, CA, USA)
E-mail: mholmes@sangamo.com

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.