home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A New Mouse Model For Cystic Fibrosis

  April, 13 2004 8:55
your information resource in human molecular genetics
The May issue of Nature Medicine unveils a new mouse model of cystic fibrosis (CF), revealing a key aspect of the disease's mechanism.

CF is a lethal disease in which a genetic mutation causes the lungs to clog with mucus. In humans, the mutation blocks chloride channels and increases sodium channels, but the same mutation in mice does not cause CF-like lung disease.

Richard Boucher and colleagues developed their model of lung disease using genetic manipulation to directly increase sodium channels in the lungs of mice. The resulting increase in salt concentration led to the decreased airway hydration and mucus plugs typically seen in CF patients.

The mouse model is the first to show that having enough liquid on airway surfaces is the key to preventing mucus buildup in the lungs. The model will be useful in testing whether therapies that improve airway hydration will be effective in CF, chronic bronchitis and other lung diseases.

Author contact:

Richard C. Boucher
University of North Carolina at Chapel Hill
Tel: +1 919 966 1077
E-mail: rboucher@med.unc.edu

Also available online.

(C) Nature Medicine press release,

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.