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Genes Predict Adverse Drug Reaction

  April, 13 2004 8:41
your information resource in human molecular genetics
A certain type of adverse drug reaction could be predicted by using gene screening, a Brief Communication in the 01 April 2004 issue of Nature (Vol. 428, No. 6982, p. 486) suggests.

Yuan-Tsong Chen and colleagues studied the genetic make-up of 44 Han Chinese patients with a form of Stevens-Johnson syndrome (SJS) - a potentially life-threatening condition associated with extreme skin inflammation and triggered by the seizure-calming drug carbamazepine. The team found that sufferers all carry the same variant of a particular gene, whereas people without this genetic 'marker' do not react against the drug.

The discovery should enable researchers to formulate a predictive genetic test for carbamazepine-induced SJS in Chinese populations, and aid understanding of the condition itself.


Yuan-Tsong Chen
Institute of Biomedical Sciences
Academia Sinica
Taipei, Taiwan
Tel: +1 886 2 2789 9104
E-mail: chen0010@ibms.sinica.edu.tw

(C) Nature press release.

Message posted by: Trevor M. D'Souza

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