home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Combatting Bacterial Infection Requires Rapid Antibody Production

 
  April, 30 2002 8:06
your information resource in human molecular genetics
 
     
Bacterial infections in the bloodstream pose a potentially lethal challenge unless neutralized by circulating antibodies that are specific for the invading pathogen. In the May issue of Nature Immunology, researchers from Kyoto University, Japan, show that if the spleen lacks early responding antibody-producing cells, the mortality associated with bacterial septicemia dramatically increases.

Antibodies are generated by B lymphocytes, which are found in multiple lymphoid organs and tissues. Tasuku Honjo and colleagues, by studying the developmental requirements of distinct B lymphocytes subsets, generated mice that did not have the early responding B cells, referred to as marginal zone (MZ) B cells. These mice were genetically deficient for B cell expression of the protein RBP-J, which is a key mediator of cell-fate determination (through its involvement in all intracellular signaling pathways that rely on members of the Notch family). The other subset of B cells, called follicular B cells, was normal in these mice, as was their ability to elicit antibody responses to protein and carbohydrate vaccines. However, these responses typically take several days to weeks to develop. The mice lacking MZ B cells failed to survive challenges with live bacteria, a situation that requires a more immediate response, indicating the critical role MZ B cells play in controlling bacterial invasions soon after the initial infection.

Author contact:

Dr. Tasuku Honjo
Faculty of Medicine
Kyoto University, Japan
Tel: +81 75 753 4371
E-mail: honjo@mfour.med.kyoto-u.ac.jp

Published Online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.