home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Do Mothers Trigger Juvenile Diabetes?

 
  April, 8 2002 8:28
your information resource in human molecular genetics
 
     
In the early stages, many diabetics show no symptoms of the disease itself and its complications. Thus screening is an important means of detecting disease. In fact, the concentration of blood antibodies against the body’s own insulin-producing cells is a strong indicator of the age at which diabetes develops. Whereas these antibodies have always been thought to be a symptom of disease rather than a cause, scientists at the University of Pennsylvania School of Medicine are now challenging that theory.

Using mouse models, Ali Naji and colleagues suggest that antibodies from the mother may be causing Type 1, or juvenile diabetes in the offspring (Nature Medicine, Vol. 8, No. 4, 01 Apr 02, p. 399). They have 3 lines of evidence to support this: mothers lacking B-cells that are able to produce antibodies and mothers genetically manipulated not to be able to produce insulin-specific antibodies, but still possessing B-cells, both yield fewer offspring with diabetes than normal mice. And embryos implanted into foster mothers that are genetically not prone to developing diabetes are less likely to develop the disease than those implanted into normal mouse mothers.

The scientists conclude that antibodies may be transmitted from mothers to infants; in those offspring that are susceptible, this transfer may trigger diabetes. Matthias von Herrath of the La Jolla Institute for Allergy & Immunology explains why the findings are so controversial in an accompanying News & Views article (p. 331).

Dr. Ali Naji
Harrison Department of Surgical Research
University of Pennsylvania School of Medicine
3400 Spruce
Philadelphia, PA 19104
Tel: +1 215 662 2066
Fax: +1 215 662 7476
Email: ali.naji@uphs.upenn.edu

Dr. Matthias von Herrath
La Jolla Institute for Allergy & Immunology
10355 Science Center Drive
San Diego, CA 92121
USA
Tel: +1 858 558 3571
Fax: +1 858 558 3579
Email Address: matthias@liai.org

(C)Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.