home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Mother's Influence Essential

 
  April, 8 2002 8:20
your information resource in human molecular genetics
 
     
A fertilized egg contains two copies of every gene, one from sperm and one the original egg cell — mother and father make equal genetic contributions. Usually, both copies are expressed in relevant embryo cells. But some genes are specifically 'imprinted' so that only the maternal or paternal copy is active — mother and father make unequal 'epigenetic' contributions. Now biologists have learnt more about this mysterious asymmetry from human cells with no maternal imprinting at all.

Fertilized mutant eggs died soon after implanting into the uterus wall, David T. Bonthron and colleagues at St James’s University Hospital, University of Leeds, UK, found (Nature, Vol. 416, No. 6880, 04 Apr 02). Further investigations of these cells should shed some much-needed light on how imprinting works, why it is necessary and why it sometimes fails.

In a News and Views article about this and closely related recent work, M. A. Surani of the Institute of Cancer and Developmental Biology, Cambridge, UK, concludes that "for the time being men are indispensable". "Even the relatively few epigenetic marks that have survived in the paternal genome are crucial for development and hence a significant barrier to virgin birth," he jokes, "but with the increasing pace of research, even this barrier might be breached in the future."

CONTACT:

David T. Bonthron
tel +44 113 206 5664
e-mail d.t.bonthron@leeds.ac.uk

Azim Surani
tel +44 1223 334088
e-mail as10021@mole.bio.cam.ac.uk

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.