home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Drugs Against Alzheimer's Disease

 
  April, 28 2001 3:35
your information resource in human molecular genetics
 
     
Fréderic Checler from the Institut de Pharmacologie Moleculaire et Cellulaire in Nice, France and Jean-Louis Kraus from Trophos, Inc., Marseille, France now describe in the May issue of Nature Cell Biology (Vol. 3, No. 5), new synthetic drugs that specifically target what may be the causal event of Alzheimer’s disease (AD), without any obvious side effects.

Patients with Alzheimer’s disease (AD) accumulate aggregates of the Amyloid-Beta protein (A-Beta) in their brain. Whether this is a cause or a consequence of the disease is still a matter of debate, but there is some evidence supporting the former hypothesis: when incubated with A-Beta in vitro, neurons die and immunization with A-Beta seems to vaccinate mice from AD.

A-Beta is the product of cleavage of its precursor, amyloid precursor protein, by an enzyme called Gamma-secretase. Blocking this enzyme might, therefore, prevent the accumulation of A-Beta and hence the progression of AD.

But, as Gamma-secretase has other substrates (such as the Notch protein and possibly the Ire1 protein) which are involved in essential processes such as defence, cell differentiation and response to stress, drugs developed to block it might have undesirable secondary effects.

Checler and Kraus have now synthesized new drugs that specifically affect A-Beta generation by Gamma-secretase, without affecting Gamma-secretase cleavage of other substrates.

CONTACT:

Frederic Checler
tel + 33 4 93 95 7760
e-mail checler@ipmc.cnrs.fr

Jean-Louis Kraus
tel + 33 4 91 82 91 41
e-mail kraus@luminy.univ-mrs.fr

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.