home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Tumour Warning In Blood Explained

  March, 22 2005 8:31
your information resource in human molecular genetics
Italian researchers have established a genetic mechanism for the long-sought-after link between cancer and blood clotting disorders, a result that might point to therapies for certain invasive cancers.

As early as 1865, doctors observed that certain blood clotting disorders serve as warning signs of occult malignancies (which lack easily detectable symptoms), but the molecules underlying this association were unknown. Now Carla Boccaccio and her colleagues report in the 17 March 2005 issue of Nature (Vol. 434, No. 7031, pp 396-400) that the human cancer-causing MET gene triggers both tumour development and blood clotting problems in mice.

The team genetically engineered mice so that they could switch on MET expression in adult mouse liver cells. When they activated the gene, it triggered slowly progressing tumours, preceded by numerous blood clots in veins and fatal internal haemorrhages. The authors show that MET boosts the levels of key enzymes involved in blood clotting, including plasminogen activator inhibitor type 1 (PAI-1) and cyclooxygenase-2 (COX-2).


Carla Boccaccio (Institute for Cancer Research and Treatment, Torino, Italy)
Tel: +39 011 9933.208; E-mail: carla.boccaccio@ircc.it

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.