home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Vital Fertilization Factor Found

 
  March, 22 2005 8:28
your information resource in human molecular genetics
 
     
Researchers have, for the first time, identified a protein on sperm that is essential for fusion with eggs during fertilization (Nature; 10 March 2005; Vol. 434, No. 7030, pp 234-238). This and other molecules involved in fusion may suggest new methods of contraception and might be targeted with new clinical treatments for infertility.

Scientists are just starting to uncover the molecules needed in order for the cell membranes of sperm and eggs to fuse. Masaru Okabe and his team used a monoclonal antibody known to block fusion of mouse sperm, and searched for the protein on sperm that is bound by this antibody. They named the protein Izumo, after a Japanese shrine dedicated to marriage.

Mice genetically engineered to lack Izumo were healthy but sterile; they produced normal-looking sperm that were unable to fuse with eggs. Human sperm also contain Izumo, the researchers found, and the antibody blocked frozen human sperm from experimentally fusing with hamster eggs.

CONTACT

Masaru Okabe (Osaka University, Japan)
Tel: +81-6-6879 8374
E-mail: okabe@gen-info.osaka-u.ac.jp

Richard Schultz (University of Pennsylvania, Philadelphia, PA, USA.)
Tel: +1 215 898 7869
E-mail: rschultz@mail.sas.upenn.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.