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A dose of Vitamin C could help alleviate the symptoms of Charcot-Marie-Tooth disease (CMT), Michel Fontés and colleagues report in the April issue of Nature Medicine.
CMT is an inherited nerve disorder that affects in 1 in 2,500 people in the US. About half of those people have the CMT-1A form, in which a genetic mutation causes nerve damage leading to muscle weakness and atrophy. In a mouse model of CMT-1A, treatment with ascorbic acid -- or vitamin C -- improved movement and increased lifespan. The compound also repaired damaged nerves and reduced the expression of the mutated gene to safe levels. Because ascorbic acid is already in use for other disorders, the researchers plan to use it in human trials for CMT-1A in the near future. Author contact: Michel Fontés
Medical Genetics, INSERM
Marseille, France)
Tel: +33 4 91 25 71 59
E-mail: Michel.Fontes@medecine.univ-mrs.fr Also available online. (C) Nature Medicine press release.
Message posted by: Trevor M. D'Souza
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