home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Stem Cells Not The Cure For A Broken Heart

 
  March, 30 2004 9:15
your information resource in human molecular genetics
 
     
Two studies shed doubt on the reported ability of certain transplanted stem cells to repair damaged heart tissue. The papers, published online by Nature this week, find no evidence to suggest that haematopoietic stem cells, which usually produce blood cells, can turn into heart cells after injection into the organ.

Two teams, led by Charles E. Murry and Leora B. Balsam, injected bone-marrow-derived haematopoietic stem cells into the damaged hearts of living mice. Both groups then followed the injected cells' fate via the use of various marker proteins. Although some of the transplanted cells seemed to survive, they did not appear to differentiate into new heart muscle cells. Instead they matured into cells of the traditional blood lineage. Balsam and colleagues observed modest benefits in some aspects of heart function after the procedure, but suggest that these may be from the stimulation of new blood vessels in the heart.

The results raise a cautionary note for interpreting the results of ongoing clinical studies where haematopoietic stem cells are injected into the heart after a heart attack.

Author contacts:

Loren Field (co-author of Dr Murry)
Indiana University
Indianapolis, IN
USA
Tel: +1 317 274 5085
E-mail: ljfield@iupui.edu

Leora Balsam
Stanford University School of Medicine
Stanford, CA
USA
Tel: +1 650 725 3828
E-mail: lbalsam@stanford.edu

Murry paper Online.

Balsam paper Online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.