home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Faster Road To Inflammation

 
  March, 16 2004 9:14
your information resource in human molecular genetics
 
     
How do the joints of patients who suffer from rheumatoid arthritis become severely inflamed? An article in the April issue of Nature Immunology reports that cells from arthritic joints make more inflammatory factors because of their response to signals that are normally involved in cell death pathways.

Fas and its ligand, FasL, usually promote cell death. Richard Pope and colleagues show that macrophages can interact with each other via Fas and FasL. Macrophages are already known to trigger arthritic joint destruction through the secretion of proteins known as proinflammatory cytokines. Their new data begin to explain how the macrophage, a useful immune system cell, becomes part of the problem, rather than part of the solution.

When Fas and FasL interact, they release the intracellular signaling pathway of another set of surface molecules, namely interleukin 1 receptor and Toll-like receptor 4, from an inhibited state. Production of destructive cytokines then ensues. When the authors blocked Fas-FasL interactions, cytokine production dropped and the severity of arthritis in a mouse model was reduced. Because Fas and FasL are present on macrophages in conditions such as atherosclerosis, these findings may prove useful for understanding other chronic inflammatory diseases.

Author contact:

Richard M. Pope
Northwestern University
Chicago, IL
USA
Tel: +1 312 908 9873
Email: rmp158@northwestern.edu

Also available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.