home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Smallpox Inoculations Show Promise

  March, 16 2004 8:54
your information resource in human molecular genetics
Tests of an experimental smallpox vaccine have produced encouraging results in monkeys and mice. The discovery may lead to an alternative for humans unable to receive current smallpox vaccines. Monkeys treated with modified vaccinia virus Ankara (MVA) were immune to monkeypox, which is similar to smallpox in humans, report Bernard Moss and colleagues in this Nature (Vol. 428, No. 6979, pp. 182-185). Monkeys that did not receive the treatment became severely ill after being exposed to monkeypox.

Monkeys were most resistant to the disease when treated with MVA and then with the existing smallpox vaccine Dryvax, the authors report. This suggests that MVA could be used as a "prevaccine", to which Dryvax could be added in the event of a specific smallpox threat, or as an alternative for those unable to take the existing vaccine for medical reasons.

In a separate study published in Proceedings of the National Academy of Sciences, Moss's team administered MVA and Dryvax to immunocompromised mice. Dryvax inoculations led to severe weight loss, skin sores, and eventual death. However, immunocompromised mice remained healthy even when treated with 1,000 times as much MVA.

The authors report that both MVA and Dryvax vaccinations led to similar levels of poxvirus immunity in healthy mice. Furthermore, MVA protected mice with specific immune deficiencies. These results suggest that MVA could be a suitable replacement for Dryvax in immunocompromised humans.


Bernard Moss
National Institute of Allergy and Infectious Diseases
Bethesda, MD
Tel: +1 301 496 9869
E-mail: bmoss@nih.gov

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.