home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Bacterial Adaptation Causes Chronic Lung Infection

 
  March, 26 2002 3:07
your information resource in human molecular genetics
 
     
The lungs of cystic fibrosis patients trigger the bacteria Pseudomonas aeruginosa to modify its surface during adaptation to the unusual conditions of the airways in such patients. In the April issue of Nature Immunology, scientists show that the immune cell receptor called TLR4 only recognizes the mutant bacterial surface, which explains why P. aeruginosa is not a problem in healthy lungs, but initiates the chronic lung inflammation commonly seen in cystic fibrosis. Samuel Miller and colleagues from Washington University show that, unlike P. aeruginosa isolated from the lungs of cystic fibrosis patients, environmental or lab-adapted strains of P. aeruginosa are not recognized by TLR4. These highly sensitive receptors signal for intricate inflammatory responses to get underway through their recognition of a surface component of P. aeruginosa called LPS. In patients, the LPS is more highly acetylated compared to the LPS from environmental or lab-adapted bacteria. These data help to explain why those with cystic fibrosis are susceptible to chronic lung inflammation after P. aeruginosa infection -- the mutated form of LPS continually stimulates inflammation, adding to the detrimental environment of the cystic fibrosis lung.

Author contact:

Samuel I. Miller
Departments of Medicine and Microbiology
University of Washington
Seattle, USA
Tel: +1 206 616 5107
E-mail millersi@u.washington.edu

(C) Nature Immunology press release.

Advance Publication available online.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.