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Genomic studies predict that 30% of all proteins are membrane associated. Identifying such proteins using similarity searches, however, is very difficult because the transmembrane sequences of such proteins change over evolutionary time much more rapidly than do soluble protein domains. Now Maria Hedman, Hans Deloof, Gunnar von Heijne, and Arne Elofsson have modified the Smith-Waterman algorithms used to detect such regions. Their new methodology significantly enhances our ability to detect similarity between membrane-associated proteins.
Improved detection of homologous membrane proteins by inclusion of information from topology predictions”
Hedman, et al. Protein Science March 1, 2002, 11 (3). (FREE ACCESS to PAPER)
Message posted by: Frank S. Zollmann
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