home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Myoglogin Induced To Form Abnormal Protein Structure Seen In Alzheimer's/CJD Diseases

  March, 9 2001 5:10
your information resource in human molecular genetics

In Alzheimer’s and Creutzfeldt–Jakob (CJD) diseases, proteins in the brain adopt an abnormal structure that makes them clump together. Christopher Dobson and colleagues, of the University of Oxford, have discovered that the muscle protein myoglobin can be induced to assume a similar guise, suggesting that adopting these alternative ‘amyloid’ structures could be feasible for many proteins, but that organisms have evolved ways to hold them at bay (Nature, Vol. 410, No. 6825, 08 Mar 2001).

The researchers found a chemical environment in which myoglobin changed from one stable form to another — the ‘fibrillar’ structure seen in prion diseases and in the brains of Alzheimer’s patients. The rogue proteins evident in the brains of Alzheimer’s and CJD sufferers may not be inherently peculiar, they could be generated just because the regulatory mechanisms that normally guard against the protein transition have broken down.


Chris Dobson
tel +44 1865 275916
e-mail chris.dobson@chem.ox.ac.uk

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.